An Ecological Framework to Understand the Efficacy of Fecal Microbiota Transplantation

Targeting Microbiota 2020 Yang Yu LiuProf. Yang-Yu Liu from Harvard Medical School &  Brigham and Women's Hospital, USA will join the Targeting Microbiota 2020 Virtual Congress which will be held on October 22-23, 2020 and give a presentation entitled "An Ecological Framework to Understand the Efficacy of Fecal Microbiota Transplantation".

Summary of the talk: Here we present an ecological framework to understand the efficacy of fecal microbiota transplantation (FMT) in treating conditions associated with a disrupted gut microbiota, using the recurrent Clostridioides difficile infection as a prototype disease. This framework predicts several key factors that determine the efficacy of FMT. Moreover, it offers an efficient algorithm for the rational design of personalized probiotic cocktails to decolonize pathogens. We analyze data from both preclinical mouse experiments and a clinical trial of FMT to validate our theoretical framework. The presented results significantly improve our understanding of the ecological principles of FMT and have a positive translational impact on the rational design of general microbiota-based therapeutics.

Targeting Microbiota 2020 Congress
October 22-23, 2020

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