Sepsis and microbiota : obstacles, recent advances and strategies

Natalia Microbiota 2018 Speakers

Dr. Natalia Beloborodova from Negovsky Research Institute of General Reanimatology, russia will join the Targeting Microbiota 2018 congress and will talk about link between Sepsis and Microbiota during her presentation "Sepsis and Microbiota : obstacles, recent advances and strategies".

According to her: "Today sepsis is seen as a life-threatening organ dysfunction caused by the dysregulation of the host response to Infection, but microbiota and their function of maintaining host metabolic homeostasis remain out of sight. In septic patients, the microbial "metabolic conveyor" of the intestine is disturbed, which leads to an excess of metabolic intermediates . The most pathogenetically significant disorders in sepsis may be associated with a violation of biodegradation of metabolites of aromatic amino acids. Some intermediate metabolites accumulated in the blood, which correlated with the progression of multiple organ failure, septic shock and death. We believe that microbiota dysfunction as an invisible organ and disruption of biodegradation of aromatic amino acid products of metabolism is a key mechanism in the development and outcome of sepsis. It is time to look for a targeted strategy to regulate microbiota signaling molecules for survival in sepsis."

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