Personalized Nutrition: New Approach for Modulating Gut Microbiota during Pregnancy

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Precision nutrition applied to pregnancy to understand the mechanisms that lead to NCD in childhood and adult life. Created with

News Release, International Society of Microbiota, France – June 29, 2022

The development of childhood and adult non-communicable diseases (NCD) is associated with environmental factors, starting from intrauterine life. A new theory finds the roots of epigenetic programming in parental gametogenesis, continuing during embryo development, fetal life, and finally in post-natal life.

Maternal health status and poor nutrition are widely recognized as implications in the onset of childhood and adult diseases. Early nutrition, particularly breastfeeding, also plays a primary role in affecting the health status of an individual later in life. A poor maternal diet during pregnancy and lack of breastfeeding can cause a nutrient deficiency that affects the gut microbiota, and acts as a cofactor for many pathways, impacting the epigenetic controls and transcription of genes involved in the metabolism, angiogenesis, and other pathways, leading to NCDs in adult life. Both maternal and fetal genetic backgrounds also affect nutrient adsorption and functioning at the cellular level.

The study of the microbiota shed lights on the microbial dysbiosis caused by unbalanced diet and its link with pregnancy complications, such as gestational diabetes and preterm birth, among others. However, the difference in genetic background as well as in the environmental factors makes difficult to define the exact mechanism controlling the microbiota in the pregnancy complications and infertility among different populations. The science of precision nutrition aims to provide precise diagnosis and personalized treatments to the individual patient taking into account genetics, microbiota composition and environmental factors.

An intertesting review by Dr. Annalisa Terranegra and her colleagues discusses the most recent evidence on maternal nutrition and breastfeeding in the development of NCD, the potentiality of the omics technologies in uncovering the molecular mechanisms underlying it, with the future prospective of applying a personalized nutrition approach to prevent and treat NCD from the beginning of fetal life.

Read the full article.

Dr. Annalisa Terranegra will join Targeting Microbiota 2022 to highlight the importance of understanding the response of the gut microbiota to different dietary intakes both in pregnancy complications and in-vitro fertilization treatments in unexplored populations from Middle East and Far East.


Media contact:

International Society of Microbiota
[email protected]

Targeting Microbiota 2022 Congress
October 19-21, 2022 - Paris, France

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