Effects of gut microbiota-derived extracellular vesicles on obesity and diabetes and their potential modulation through diet

This mindblowing review highlights the beauty of the gut microbiota, and its endless potential in controling obesity and diabetes via micorbiota-derived extracellular vesicles .

Obesity and diabetes are reaching pandemic proportions. It is necessary to unravel the mechanisms underlying their pathophysiology, especially their interconnection with gut microbiota dysbiosis.

Today, secretion of gut microbiota-derived extracellular vesicles is gaining special attention, being key factors that could mediate gut microbiota-host communication. Extracellular vesicles (EV) derived from gut microbiota and probiotic bacteria allow to encapsulate a wide range of bioactive molecules (such as/or including proteins and nucleic acids) that could travel short and long distances to modulate important biological functions with the overall impact on the host health. EV-derived from specific bacteria induce differential physiological responses.

This review is the newest pieces of evidence concerning the potential role of gut microbiota and probiotic-derived EV on obesity and diabetes onset, progression, and management, through the modulation of inflammation, metabolism, and gut permeability. It also discusses the role of certain dietary patterns on gut microbiota-derived EV profile and the clinical implication that dietary habits could have on metabolic diseases progression through the shaping of gut microbiota-derived EV.

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Authors: Díez-Sainz, Ester et al.

To access the full review press here.