Gut Microbiota-Derived Extracellular Vesicles on Obesity, Diabetes and Metabolism

Dr Fermin I. Milagro

Dr. Fermin I. Milagro, from the University of Navarra (Spain), will be discussing his most recent findings on "Gut Microbiota-Derived Extracellular Vesicles on Obesity, Diabetes and Metabolism".

Gut microbiota dysbiosis has been proposed as a contributing factor to the etiology of obesity and diabetes. In this context, gut microbiota-derived extracellular vesicles (EV) are gaining attention as mediators in the gut microbiota-host communication. EV derived from gut microbiota and probiotic bacteria contain a myriad of bioactive molecules (including proteins, microRNAs, and lipids) that could modulate important biological functions with overall impact on host health. It has been reported that EV-derived from specific bacteria induce different physiological responses. For example, those from Akkermansia muciniphila are known to ameliorate obesity and diabetes in mice. Some of the underlying mechanisms are the modulation of gut permeability, inflammation, and host metabolism. For these reasons, nutritional and pharmacological approaches based on the administration of EV derived from probiotics or gut microbiota bacteria should be viewed as a new therapeutic tool to treat obesity and diabetes. Also, the characteristics and amount of gut microbiota-derived EV could be modulated through dietary means to prevent and treat metabolic diseases.

Targeting Microbiota 2022 Congress
October 19-21, 2022 - Paris, France