Alerts

Prof. Maria Cecilia Giron Appointed President of ISM, Pioneering Microbiota Research

GIRON

The scientific Board announce the appointment of Prof. Maria Cecilia Giron as the President of the International Society of Microbiota (ISM). This appointment marks a significant milestone in her illustrious career and promises to be a turning point in the field of microbiota research.

Dr. Giron has an extensive and impressive background in the field of pharmacology and clinical studies. Her invaluable contributions are evident through her roles in various prestigious committees, including the Ethics Committee for Clinical Studies at Padova University Hospital, the Ethics Committee for Oncological Clinical Trials at the Veneto Institute of Oncology, and the Veneto Region Medicines Evaluation Committee.

A true pioneer in her field, Dr. Giron's research has been instrumental in shedding light on the intricate relationship between gut microbiota and intestinal function in both normal and pathological conditions. Her dedication to advancing our understanding of microbiota's role in human health is underscored by her impressive portfolio of over 60 peer-reviewed publications.

Under her leadership, we anticipate that ISM will continue to flourish and lead the way in microbiota research, forging new paths and fostering collaboration to uncover the profound implications of microbiota in health and disease. We congratulate Prof. Maria Cecilia Giron on this remarkable achievement and eagerly await the exciting developments she will bring to the forefront of microbiota research.

Recognizing Prof. Lena Öhman's Outstanding Scientific Contribution to Microbiota Research at Targeting Microbiota 2023

Celebrating Prof. Lena Öhman’s Outstanding Scientific Contribution to Microbiota Research at Targeting Microbiota 2023

 Ohman  ISM Best scientific Contribution 1

We are delighted to celebrate the remarkable scientific contribution of Prof. Lena Öhman from the University of Gothenburg, Sweden, during Targeting Microbiota 2023.
She was awarded the ISM Scientific Contribution 2023.

Prof. Öhman, with a distinguished career spanning from her PhD thesis defense in 2002 to her recent appointment as a full professor in 2020, has made significant strides in the field of microbiota research.

A Pioneering Career

Prof. Öhman’s journey in academia has been nothing short of extraordinary. After completing her doctoral studies, she embarked on a journey that took her to Danone Research and INRAE Île-de-France - Jouy-en-Josas for a research sabbatical in 2012-2013. Her diverse experiences have enriched her perspective, leading to innovative insights in her field.

Unraveling Complexities in Gastrointestinal Disorders

During her captivating presentation at Targeting Microbiota 2023, Prof. Öhman delved deep into the intricate challenges posed by gastrointestinal disorders. Her talk not only explored the nuances of monitoring and diagnosing these diseases but also illuminated the mechanisms that underlie their initiation and persistence. Of particular significance was her examination of the potential of fecal gut microbiota and metabolite signatures as promising biomarkers for gastrointestinal disorders.

Dedicated Research Group

Prof. Öhman’s commitment to advancing our knowledge of gastrointestinal diseases extends beyond the lecture hall. She leads a dynamic research group at the University of Gothenburg, tirelessly working to uncover how gut microbiota and immune activity influence the course of these disorders. Their collective mission is to identify microbiotic and immunological indicators that can guide therapy decisions and improve outcomes for patients.

Prof, Öhman shared with the International Society of Microbiota: "We aim to continue to explore the potential of intestinal microbiota and metabolome as diagnostic biomarkers for inflammatory bowel disease, but also for colitis-associated colon cancer. Furthermore, we aim investigate the underlying principles of how commensal microbiota govern intestinal T cells and B cells in inflammatory bowel disease".

Innovative Approaches

In addition to discussing biomarkers, Prof. Öhman shared insights into the prospective use of in vitro cell culture models as powerful tools for studying the mechanisms of disease. Her comprehensive presentation illuminated the current state of research in this field, inspiring fellow researchers and clinicians alike.

We extend our heartfelt congratulations to Prof. Lena Öhman for her outstanding achievements and dedication to advancing our understanding of gastrointestinal disorders and the role of gut microbiota. Her pioneering contributions in the field are truly commendable, and we eagerly anticipate further advancements in this critical area of research.

Join Us in Celebrating Excellence

We invite you to join us in celebrating the excellence and dedication of Prof. Lena Öhman in the field of microbiota research. Her contributions have undoubtedly paved the way for a deeper understanding of gastrointestinal disorders and hold the promise of improved diagnostics and therapies in the future.

Stay tuned for more groundbreaking insights from leaders in microbiota research at Targeting Microbiota 2023.

Best Poster Award at Targeting Microbiota 2023 Spotlights Innovative Research

Best Poster 2023

Targeting Microbiota 2023 Best Poster Presentation Award

The International Society of Microbiota (ISM) is delighted to extend its warmest congratulations to Kelly Conde Pérez, from the Universitary Hospital of A Coruña, Spain, for her outstanding poster presentation titled:

Parvimonas Micra Translocates From Subgingival Pockets to Tumors in Colorectal Cancer Patients."

This remarkable poster presentation has illuminated a potential breakthrough in our understanding of the microbiota's role in colorectal cancer. Kelly's work suggested a fascinating link between the oral pathogen Parvimonas micra and tumors in colorectal cancer patients. The data presented indicated that P. micra not only coexists with other periodontal pathogens but also migrates to the gut, liver, and periodontal pockets. The efficiency of bacterial translocations appears to be enhanced when microorganisms form consortia.

Moreover, RNA-seq analysis provided compelling evidence that oral microbes exhibit increased activity within tumor tissues compared to healthy tissue. This groundbreaking research implies that Parvimonas micra, in conjunction with other pathobionts, may translocate from the oral cavity to the gut. This revelation opens up exciting possibilities, as P. micra could potentially serve as a non-invasive biomarker for colorectal cancer.

Kelly Conde Pérez's work embodies the spirit of innovative microbiota research, and her findings hold immense promise for advancing our understanding of colorectal cancer and its relationship with the microbiome.

The ISM commends Kelly for her exceptional contribution to the field and encourages young investigators to pursue their passion for microbiota research. We are committed to keeping you updated with the latest discoveries and advancements in this dynamic field. Stay engaged and stay tuned for more groundbreaking research!

Outstanding Presentation on Microbiota Manipulation for Cdkl5 Deficiency Disorder Receives Top Honors at Targeting Microbiota 2023

ISM 2023 Best Short Oral

Targeting Microbiota 2023 Best Short Oral Presentation Award

Francesca Damiani, from Scuola Normale Superiore, Italy, has been honored with the prestigious Best Short Oral Presentation award at Targeting Microbiota 2023. Her exceptional talk, titled "Microbiota Manipulation as a Potential Therapeutic Strategy to Improve Clinical Symptoms in CDKL5 Deficiency Disorder," stood out as a groundbreaking contribution to the field.

Cyclin-Dependent Kinase-Like 5 (CDKL5) deficiency disorder (CDD) is a rare X-linked developmental encephalopathy rooted in pathogenic variants of the CDKL5 gene. Beyond the array of neurological symptoms associated with CDD, patients frequently contend with gastrointestinal issues and underlying immune dysregulation as comorbidities. Dr. Damiani's research has shed light on the possible connection between these challenges and disturbances in the intestinal microbiota, specifically the presence of dysbiosis in CDD patients.

In her enlightening presentation, Dr. Damiani unveiled the promising clinical application of microbial manipulation as a non-invasive avenue to alleviate symptoms in individuals affected by CDD.

Dr. Damiani shared with the Internation Society of Microbiota (ISM) "Our research sheds light on the previously unexplored role of the gut microbiota-brain axis in influencing the behavioral and functional deficits observed in mouse models of CDD. In the future, we aim to elucidate the specific signals and pathways that mediate this connection, potentially offering innovative avenues for microbiota-based interventions in clinical practice. Moreover, to enhance the translational relevance of our findings, we plan to investigate the therapeutic potential of probiotic supplementation in CDD mice. In summary, targeting the intestinal microbiota could serve as a non-invasive alternative strategy to alleviate symptoms in CDD patients, and hopefully, in other neurodevelopmental disorders".

The International Society of Microbiota (ISM) extends its heartfelt congratulations to Dr. Damiani for her exceptional achievement. We eagerly anticipate learning more about her future research endeavors as she continues to make strides in the field of microbiota research.

Domestic Cleaning and Human Microbiome - Is There a Link?

Markus Egert updated 2023Prof. Markus Egert from Furtwangen University and active member of the ISM scientific committee, will chair a session on "Environment, Lifestyle & Microbiota: A "One Health" Approach" during Targeting Microbiota 2023.

 In industrialized countries, people spend up to 90% of their lifetime indoors. However, potential links between the indoor microbiome, the microbiome of daily used objects, the human microbiome and health and well-being are only poorly understood.

Prof. Egert will present a talk that will summarize current knowledge about how domestic cleaning and hygiene measures, predominantly aiming at the prevention of infectious diseases, might influence and shape the human microbiome and its effects on human health. His talk will conclude with suggestions on what "microbiome-friendly" household hygiene could look like. 

Prof. Egert's talk will be titled: "Domestic Cleaning and Human Microbiome - Is There a Link?"


About Prof. Egert

Markus Egert is professor for Microbiology and Hygiene at Furtwangen University of Applied Sciences (Black Forest, Germany). His work aims at a deeper understanding of the structural and functional interactions of microbial communities with humans.  He was one of the first researchers to apply the so-called RNA-based stable isotope probing technique (RNA-SIP) to intestinal ecosystem in order to identify prebiotics-degrading bacteria. In addition, he is known for his pioneering work on the microbiome of objects of daily use, such as kitchen sponges, spectacles and washing machines, and the hygienic relevance that goes with it.


Join Targeting Microbiota 2023 to learn more about Prof. Egert's talk. 

You can share your related work by submitting your abstract.

Targeting Microbiota 2023 Congress
October 17-19, 2023 - Venice
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Mapping the Kitchen Microbiota in Five European Countries

Brigitte MoenDr. Birgitte Moen from Nofima—Norwegian Institute of Food, Fisheries and Aquaculture Research, Norway will join Targeting Microbiota 2023 on October 17-19 to present her latest research "Mapping the Kitchen Microbiota in Five European Countries".

Join Targeting Microbiota 2023 to learn more about Dr. Moen's talk. 

You can share your related work by submitting your abstract.

Targeting Microbiota 2023 Congress
October 17-19, 2023 - Venice
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Gut microbiota and prebiotics in Parkinson's disease: The RESISTA-PD Trial

Andreas SchwiertzProf. Andreas Schwiertz, Institute of Microecology, Germany will present his latest research during Targeting Microbiota 2023 on October 17-19 in a talk titled "Gut microbiota and prebiotics in Parkinson's disease: The RESISTA-PD Trial".

The composition of the gut microbiome is linked to multiple diseases, including Parkinson’s disease (PD). Bacteria producing short-chain fatty acids (SCFAs) and fecal SCFA concentrations are reduced in PD. SCFAs exert various beneficial functions in humans. In the interventional, monocentric, open-label clinical trial RESISTA-PD Prof. Schwiertz and his colleagues aimed at altering fecal SCFAs by an 8-week prebiotic intervention with resistant starch (RS).

In the PD + RS group, fecal butyrate concentrations increased significantly, and fecal calprotectin concentrations dropped significantly.  Clinically, Prof. Schwiertz and his team observed a reduction in non-motor symptom load in the PD+RS group.


About Prof. Prof. Schwiertz

Dr. Andreas Schwiertz is a microbiologist and molecular biologist. He trained at the Carl von Ossietzky University, Oldenburg (GER), the University College Cork (IRL) and Sate University of St. Petersburg (RUS). He received his PhD from the University of Potsdam (GER), where he trained under Prof. Michael Blaut in human gastrointestinal microbiology and on probiotics. In 2012 he received his lecturer qualification from the Justus Liebig University of Giessen on gastrointestinal microbiology where he is associated professor. In 2003 he joined the Institute of Microecology in Herborn, where he serves currently as CEO and CSO.


Join Targeting Microbiota 2023 to learn more about Prof. Schwiertz's talk. You can learn more about Targeting Microbiota 2023 program here.

Targeting Microbiota 2023 Congress
October 17-19, 2023 - Venice
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Microbiota, Enteric Nervous and Immune Systems: Barrier Defenses against Foodborne Pathogens Carriage in Poultry

Valentina Caputi Targeting Microbiota 2023Dr. Valentina Caputi, United States Department of Agriculture, Agricultural Research Service, USA, will join Targeting Microbiota 2023 on October 17-19 to present her latest research "Microbiota, Enteric Nervous and Immune Systems: Barrier Defenses against Foodborne Pathogens Carriage in Poultry".

The gastrointestinal tract is the largest body surface in contact with commensal microorganisms (or microbiota) and with pathogens, therefore the intestinal wall possesses a sophisticated system of barriers that protects the host from the translocation of pathogens, their molecular profiles, or environmental toxins in extra-intestinal tissues. The intestinal epithelium provides the first barrier defense against bacterial- or toxins translocation and its function is finely modulated by the immune system. Several studies have explored avian intestinal epithelial barrier alterations following Salmonella or Campylobacter infection. Submucosa and smooth muscle layers are located underneath the intestinal epithelium. These tissues are densely innervated by the enteric nervous system (ENS), a complex network of neurons and glial cells capable of functioning independently from the brain. The ENS is the principal coordinator of gut motility, peristalsis, nutrient absorption, and fluid secretion.

However, recent studies have shown that enteric neuronal populations are responsible for producing proinflammatory cytokines, thus stimulating the intestinal immune cells to release antimicrobial peptides against Salmonella infection in mammals. These results provide evidence of solid neuroimmune interactions in the gut that strengthen the canonical epithelial barrier against pathogenic infections such as Salmonella. The role of enteric neuroimmune interactions in chicken broilers affected by Salmonella or other foodborne pathogens has not been explored yet, and this research will provide a novel approach to understanding foodborne pathogens infection in poultry and ultimately formulate antibiotic alternatives aimed at preserving the integrity and function of the intestinal neuroimmune barriers. 

Join Targeting Microbiota 2023 to learn more about Dr. Caputi's talk. 

You can share your related work by submitting your abstract.

Targeting Microbiota 2023 Congress
October 17-19, 2023 - Venice
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Skin Microbial Changes during Space Flights

Pamela Tozzo 1Dr. Pamela Tozzo from the University of Padova, Italy will join Targeting Microbiota 2023 on October 17-19 to present her latest research "Skin Microbial Changes during Space Flights".

Join Targeting Microbiota 2023 to learn more about Dr. Tozzo's talk. 

You can share your related work by submitting your abstract.

Targeting Microbiota 2023 Congress
October 17-19, 2023 - Venice
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Microbiota & Myelinazation: The Latest Findings

Microbiota 2022 Congress speaker Maria Cecilia GironProf. Maria Cecilia Giron, local organizer of Targeting Microbiota 2023, University of Padova, Italy will join the conference and will give a presentation entitled "Microbiota & Myelinazation: The Latest Findings".

Join us in Targeting Microbiota 2023 and benefit from the experience of Prof. Giron. Don't forget that you can share your related work by submitting your abstract.

Targeting Microbiota 2023 Congress
October 17-19, 2023 - Venice
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Microbiota, Prophages & Phage Therapy: The Missing Link

Marvin Edeas 4Prof. Marvin Edeas Founder & Chairman of ISM's Committee, Institut Cochin, INSERM, Université de Paris, France will join Targeting Microbiota 2023 on October 17-19 to present a talk entitled "Microbiota, Prophages & Phage Therapy: The Missing Link".

Join Targeting Microbiota 2023 to learn more about Prof. Edeas's talk. 

You can share your related work by submitting your abstract.

Targeting Microbiota 2023 Congress
October 17-19, 2023 - Venice
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COVID 19 and Microbiota - A Story with a Long Tail

Prof Peter C. Konturek

Prof. Peter C. Konturek, President of ISM from  Teaching Hospital of the University of Jena, Germany will present a talk entitled "COVID 19 and Microbiota - A Story with a Long Tail".

Join Targeting Microbiota 2023 to learn more about Prof. Konturek's talk. 

You can share your related work by submitting your abstract.

Targeting Microbiota 2023 Congress
October 17-19, 2023 - Venice
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Computational Modeling Microbial Community Networks: Pros and Cons

Barbara Di CamilloProf. Barbara Di Camillo, University of Padova, Italy will join Targeting Microbiota 2023 on October 17-19 to present her latest research "Computational Modeling Microbial Community Networks: Pros and Cons".

Join Targeting Microbiota 2023 to learn more about Prof. Di Camillo's talk. 

You can share your related work by submitting your abstract.

Targeting Microbiota 2023 Congress
October 17-19, 2023 - Venice
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Marine Heatwaves and Microbiome in the Mediterranean Sea: Insights From Non Model Organism Manila Clam

Dr. Martino

Dr. Maria Elena Martino, University of Padova, Italy, will present her latest research during Targeting Microbiota 2023 on October 17-19 in a talk titled "Marine Heatwaves and Microbiome in the Mediterranean Sea:  Insights From Non Model Organism Manila Clam".

Extreme climatic events like Marine Heatwaves (MHWs) are becoming more intense and frequent and are severely threatening ecosystems’ health. Specifically, marine ecosystems are facing an increase in the prevalence of pathogenic microbes, causing significant shifts in the ecology and evolution of animal-microbiome symbiosis in marine environments. However, how extreme climate events shape the evolution and the adaptation of marine hosts and their microbiomes is still poorly understood.

Here, Dr. Martino and her team characterized the effect of heat waves on the microbiome of Manila clam Ruditapes philippinarum, one of the most widely farmed clam species worldwide, and investigated the ultimate effect on host health.


 You can learn more about Dr. Martino's talk this October in Venice.

Targeting Microbiota 2023 Congress
October 17-19, 2023 - Venice
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Evaluation of Transitional Changes Shaping the Infants’ Gut Microbiota in Early Life: The CI.EMME Study

Prof. Di PilatoProf. Vincenzo Di Pilato from the University of Genoa, Italy will join Targeting Microbiota 2023 on October 17-19 to present his latest research "Evaluation of Transitional Changes Shaping the Infants' Gut Microbiota in Early Life: The CI.EMME Study".

The gut microbiota (GM) consists in a densely populated ecosystem that, from birth onwards, colonizes the intestinal tract through a highly dynamic processes, fundamental for health later in life. Indeed, disturbance of the GM in early life may results in lifelong consequences, and certain microbial features can be associated with disease states that are manifested at later stages, including asthma, inflammatory bowel disease, and metabolic disorders.

In the context of the CI.EMME study, Prof. Di Pilato and his team, longitudinally investigated the transitional changes of GM in a cohort of infants, expanding knowledge about the microbiota composition and maturation paths in early life.

Join Targeting Microbiota 2023 to learn more about Prof. Di Pilato's talk. 

You can share your related work by submitting your abstract.

Targeting Microbiota 2023 Congress
October 17-19, 2023 - Venice
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Microbiome Engineering: Reprograming microbes to rewire host-microbiome interactions

Matthew ChangDr. Matthew Chang from the National University of Singapore, Singapore will join the Targeting Microbiota 2023 congress and will talk about "Microbiome Engineering: Reprograming microbes to rewire host-microbiome interactions".

The wealth of knowledge on the human microbiota composition and its roles in health and disease has recently spurred the development of novel therapeutic strategies. Moreover, with an array of genetic tools that are readily available, programmable genetic circuits can be designed, genomes can be edited and rewritten, and cells can be reprogrammed to foster novel microbiota-based interventions.

In this talk, Dr. Chang's recent work on engineering gut-resident microbes as versatile platforms equipped with clinically relevant functionalities will be presented. A particular emphasis will be placed on his team's efforts to transform gut microbes into live biotherapeutics with prophylactic and therapeutic efficacy against pathogenic infections and chronic metabolic diseases.

This work provides a strong foundation for engineering microbes to modulate host-microbiome interactions and supports the use of live biotherapeutics as a viable strategy for clinical intervention.


About Dr. Chang

Matthew Chang is Director of the National Centre for Engineering Biology, Singapore Consortium for Synthetic Biology, Wilmar-NUS Corporate Laboratory, and NUS Synthetic Biology for Clinical and Technological Innovation, and Dean’s Chair in Medicine and Associate Professor of Biochemistry and Synthetic Biology at the Yong Loo Lin School of Medicine at the National University of Singapore. His research focuses on studying the engineering of biology to develop autonomous, programmable cells for biomedical and biomanufacturing applications. He co-founded the Global Biofoundry Alliance and the Asian Synthetic Biology Association and serves as Co-Chair of the World Economic Forum’s Global Future Council on Synthetic Biology.


Join Targeting Microbiota 2023 to learn more about Dr. Chang's talk. 

You can share your related work by submitting your abstract.

Targeting Microbiota 2023 Congress
October 17-19, 2023 - Venice
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Environmental Drivers of Avian Enteric Neuroendocrine Plasticity in the Context of Foodborne Pathogen Carriage

Joshua Lyte 1Dr. Joshua Lyte, United States Department of Agriculture, Agricultural Research Service, USA, will join the Targeting Microbiota 2023 congress to talk about: "Environmental Drivers of Avian Enteric Neuroendocrine Plasticity in the Context of Foodborne Pathogen Carriage".

Environmental pressures represent an omnipresent threat across the diverse phases of poultry production in the 21st century. Research directed at mitigating the deleterious effects of environmental stress on the avian gastrointestinal tract necessitates the identification of mechanistic pathways that sit at the nexus of host and microbiota.

The research approach that Dr. Lyte and his team employed has its basis in common mechanistic pathways that are shared among diverse forms of environmental stressors. Those pathways principally involve the host’s neuroendocrine response to stress as well as the response of the gut microbiota whose composition and function are critical to gut homeostasis and avian well-being. 

Microbial endocrinology, which is the study of the intersection of two seemingly disparate fields, neuroendocrine physiology and microbiology, and the bi-directional communication between both, that is at the core of our approach to devising new strategies to combat environmental stressors in food production animals. The remarkable integration of the bird’s neuroendocrine physiology and its microbiota is due to the evolutionary-based fact that each shares a range of neurochemicals, principally those related to the stress response, that permit bi-directional communication between the two that ultimately influences host gut function.

This talk will focus on the avian gut as the anatomical region where the host and microbiota interact and represents the area that can most easily be leveraged to deal with environmental stressors. As will be discussed, the design of new antibiotic alternative strategies that seek to manage the intersection of host neuroendocrine physiology and microbiota is one of the most promising avenues for dealing with the negative effects of environmental stress which may drive avian susceptibility to foodborne pathogen carriage.

Join Targeting Microbiota 2023 to learn more about Dr. Lyte's talk. 

You can share your related work by submitting your abstract.

Targeting Microbiota 2023 Congress
October 17-19, 2023 - Venice
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Effect of Gut Microbiota Regulation on Non-Alcoholic Fatty Liver Disease

Yu Chen 2Dr. Yu Chen from The 7th Affiliated Hospital of Southern Medical University, China will join the Targeting Microbiota 2023 congress to talk about: "Effect of Gut Microbiota Regulation on Non-Alcoholic Fatty Liver Disease".

Non-alcoholic fatty liver disease (NAFLD) is currently the most prevalent cause of chronic liver disease. Alteration of the microbiota seem to be key in the development and progression of NAFLD. Gut microbiome regulation, such as Faecal Microbiota Transplantation (FMT) and supplementation in Akkermansia muciniphila , was paving the way as the therapeutic target for NAFLD.

Join Targeting Microbiota 2023 to learn more about Dr. Chen's talk. 

You can share your related work by submitting your abstract.

Targeting Microbiota 2023 Congress
October 17-19, 2023 - Venice
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Gut Microbiota & Microbiota-Derived Metabolites Role in Endometriosis

RamakrishnaKommaganiDr. Ramakrishna Kommagani from Baylor College of Medicine, USA will join the Targeting Microbiota 2023 congress to talk about: "Gut Microbiota & Microbiota-Derived Metabolites Role in Endometriosis".

Join Targeting Microbiota 2023 to learn more about Dr. Kommagani's talk. 

You can share your related work by submitting your abstract.


 Targeting Microbiota 2023 Congress
October 17-19, 2023 - Venice
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Microbiota and Interactions with Gut and the Enteric Nervous System

Karl Herbert SchäferProf. Karl-Herbert Schäfer from Kaiserlautern University of Applied Sciences, Germany will join the Targeting Microbiota 2023 congress to talk about: "Microbiota and Interactions with Gut and the Enteric Nervous System".

The gut contains billions of bacteria, that have long been neglected, and which have been seen, at best, as potential trouble makers in cases of diseases. During the last decades, the view of the enteric microbiome changed a lot. It is known now that it is influencing the quality of the gut barrier, producing legions of metabolites that influence both gut and enteric nervous system, changing i.e. gut motility or the inflammatory status of the gut wall.

Bacterial lipopolysaccharides might immediately impact i.e. the proliferation of neural stem cells within the ENS, or influence their differentiation. Bacteria can produce neurotransmitters such as GABA and serotonin, along with short chain fatty acids (SCFA) such as butyrate. Extracellular vesicles, produced by the bacteria, can carry this molecules along the mucosal barrier and might influence directly the activity of the ENS and thus the whole gut. Moreover, bacteria can produce Amyloid-like Protein Fibrils (ALFs) such as curli, which might initiate pathological processes in neurodegenerative diseases.

The impact of individual bacterial strains or LPS as a major molecule provided by gram negative bacteria upon gut and ENS has been investigated by Prof. Schäfer and his colleagues using primary cultures of the isolated myenteric plexus, analysing its growth or electrical responses after “bacterial” stimulation. Whole gut segments have been used in organ bath approaches to investigate alterations of gut motility when being perfused with bacteria or bacterial supernatants.

Join Targeting Microbiota 2023 to learn more about Prof. Schäfer's research and obtained data.

Targeting Microbiota 2023 Congress
October 17-19, 2023 - Venice
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Arresting microbiome development limits immune system maturation and resistance to infection in mice

Michael A. Silverman

Dr. Michael Silverman from the University of Pennsylvania, USA will join the Targeting Microbiota 2023 congress and will talk about "Arresting microbiome development limits immune system maturation and resistance to infection in mice".

Join Targeting Microbiota 2023 to learn more about Dr. Silverman's talk. 

You can share your related work by submitting your abstract.

Targeting Microbiota 2023 Congress
October 17-19, 2023 - Venice
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Microbiota in the Press & Media

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