You have until September 21 to submit your abstracts for Targeting Microbiota World Congress 2015


The Scientific Committee of International Society of Microbiota and Targeting Microbiota World Congress 2015 invites all scientists, academics and industrials to present their researches in microbiota area during the 3rd World Congress on Targeting Microbiota, which will be held in Paris, at Institut Pasteur on October 21-23, 2015.


Juristical hurdles and possibilities for companies providing faecal transplant services


According to definition in the broadest of terms, a drug is a chemical substance that has known biological effects on humans or other animals. However, what is a faecal transplantation in a legal context?

As representing a company with years of experience in the preparation of individual drugs based on microorganism,  Dr Andrews Schwiertz from MVZ Institut für Mikroökologie, Germany will present their experience with the German registration bodies and authorities on application for faecal transplant preparations under GMP conditions.

For more information about the program of Targeting Microbiota Congress:



What are the evolution and challenges of NGS technologies for microbiota analysis and their validation for diagnostic?

MassartSébastien Massart, Business Development Manager at DNAVision, Belgium will give a strategic presentation about NGS technologies, their updates, evolution and validation for the diagnosis during the workshop organized on October 21, 2015 about Exploration & Sequencing of Human Microbiota: The Perfect Signature.

NGS technologies have revolutionized the landscape of microbiota studies. Through a critical overview, the talk will review the pros and cons of the 3 main protocols to study microbiota by NGS. The challenges and opportunities of these developments will be underlined during the workshop as well as the road toward their use in diagnostics.

If you would like to access to the complete program of the congress and register:


A Special Session dedicated to Practical Issues and Regulation of Fecal Microbiota Transplantation is organized during Targeting Microbiota 2015

FecalTransplantationThe aim of this special session is to discuss last advances, practical issues, limits of the intestinal microbiota and Fecal microbiota transplantation in various pathologies.


The International Society of Microbiota awards 3 Scientifics


During Targeting Microbiota 2014 which was be held in Pasteur Institute, the Scientific Committee of International Society of Microbiota awarded:

- Dr. Gurumoorthy Krishnamoorthy for his Scientific Contribution about: "The gut-brain axis in the CNS autoimmunity"

please click here for more information

- Dr.Tewodros Debebe for his Short Oral Presentation about: "The microbiota of the long living naked mole rat". 

 please click here for more information

 - Dr. Laurent Naudon for his Poster Presentation about: "Overproduction of indole by gut microbiota increases anxiety and depressive-like behaviours in rats".

 please click here for more information

ISM discerned the award of Short Oral Presentation to Dr. Tewodros Debebe

Dr. Tewodros Debebe,  from University of Leipzig,Germany was awarded for his Short Oral Presentation by ISM Scientific Committee during the 2nd International Congress on Targeting Microbiota which was held in Pasteur Institut on October 16,17.


ISM is pleased to award Dr. Laurent Naudon for his Poster Presentation



On behalf of the Scientific Committee, we congratulate Dr. Laurent Naudon from CNRS, France for his award for Poster Presentation during Targeting Microbiota World Congress which was held in Institut Pasteur, Paris.

Dr. Laurent Naudon has presented a Poster about "Overproduction of indole by gut microbiota increases anxiety and depressive-like behaviours in rats".

PosterpresentationAccording Dr. Laurent Neudon: "The gut microbiota ecosystem is in a dynamic balance throughout life. A disturbance of this balance can cause a change in the profile of metabolites produced by this ecosystem. Some of these metabolites are questioned to be involved in the pathophysiology of brain disorders, including mood disorders. Among them, indole is the product of the transformation of tryptophan by the enzyme tryptophanase (EC, encoded by several bacterial species of the gut microbiota. The genes encoding for tryptophanase (TnaA) were isolated from the human metagenomic catalog (3.3 M) by using a bioinformatic pipeline developed in our laboratory. Analysis of the distribution of the isolated genes from the human gut microbiota revealed that they are harboured by Bacteroides, Clostridium and Roseburia.

This study aims to investigate whether an overproduction of indole by the gut microbiota can alter performance in behavioural tasks in rats, including memory, anxiety and depressive-like behaviours. For this purpose, we used a model of gnotobiotic F344 male adult rats colonized at birth with a wild-type strain of Escherichia coli, which naturally produces indole [I+ rats], or with its knock-out mutant for the tryptophanase gene, which cannot produce indole [I- rats]. We checked the absence of indole in the gut of I- rats, while indole concentration reached around 100 nmol/g dry matter in the feces of I+ rats, i.e. four times as much as in conventional rats. Furthermore, indole was absorbed through the gut mucosa as ascertained by the presence of its major detoxification metabolite, indoxylsulfate, in the urine of I+ rats. I+ rats displayed greater anxiety-like behaviours than their I- counterparts in several anxiety tests (elevated plus maze, open-field and novelty task). This was accompanied by a greater depressive-like behaviour in the tail suspension test. In both groups, memory performances were similar in the novel object recognition task. Our study demonstrates that a difference in indole production by the gut microbiota leads to behavioural differences in rats. The hypothetical routes whereby indole affects the brain still remain to be established. However, the present data strongly encourage considering the metabolites produced by the gut microbiota as potential actors in the emergence, maintaining and therapy of brain disorders."


For more information about Targeting Microbiota 2014:




The International Society of Microbiota published a press released concerning Microbiota Science

The IMICRO LOGO bleu CADREnternational Society of Microbiota (ISM) published the final program of the 2nd World Congress on Microbiota which will be held at Pasteur Institute.

The ISM Scientific Committee highlighted the strategic role and vision concerning microbiota.


The President of Institut Pasteur will address his welcome during the opening of Targeting Microbiota congress

Institut Pasteur2During the opening ceremony of the 2nd World Congress on Targeting Microbiota, which will be held at Institut Pasteur, Paris on October 16-17,
Pr Christian Bréchot, Président of Institut Pasteur, will address his welcome and remarks.

He will be represented by Pr Philippe Sansonetti from Institut Pasteur, a well-known researcher in microbiota field.

To access to Targeting Microbiota Program, please follow this link.

To access to the list of attendees, please follow this link.

We look forward welcoming you at Pasteur Institute soon.

John Edwards

A record of academic and industrial participants for Targeting Microbiota 2014


This year, Pasteur Institute will host Targeting Microbiota World Congress on October 16-17, 2014.

Targeting Microbiota 2014 will gather more than 500 participants coming from industries and academies for two days from 45 countries.

To access to the updated list of academic and industrial participants, please click here.


Targeting Microbiota will gather high distinguished speakers

MicrobiotaSpeakersThe Scientific Committee thanks all well-known speakers of Targeting Microbiota World Congress:

David Berry, University of Vienna, Vienna, Austria
Rémy Burcelin, INSERM, Toulouse, France
Patrice D. Cani, Louvain Drug Research Institute, Brussels, Belgium


Pr Gouyon will talk about Microbiota Evolution, Competition & Cooperation


Pr Pierre-Henri Gouyon, from Museum of Natural History, Paris, France will open the congress by highlighting the evolution, competition & cooperation of cells & Microbiota.

According Pr Gouyon: “Nothing in biology makes sense except in the light of Evolution” Th. Dobzhansky stated in the mid XXth century. Indeed, our comprehension of biology lies on the theory developed by Darwin in 1859 and improved by the adjunction of genetics. Evolution proceeds by variations progressively lost or fixed through processes including chance and differential survival and/or reproductive success. The main process leading Evolution is thus the competition among different genetic entities through the differential success of the individuals carrying and reproducing them. But the fact that competition is a leading force does not imply that cooperation does not exist.

To access to the global program of the conference, please click here.

Targeting Microbiota 2014

Targeted modulation of the gut microbiota-host interaction reveals novel mechanisms involved in host response during obesity

CaniPr Patrice Cani, from Catholic University of Louvain, Belgium will discuss about "Targeted modulation of the gut microbiota-host interaction reveals novel mechanisms involved in host response during obesity", during the the 2nd World Congress on Targeting Microbiota which will be held at Institut Pasteur, on October 16-17, 2014.


“10 minutes to convince” dedicated to start-ups and biotech companies


The Scientific Committee of Targeting Microbiota is pleased to invite Startup and Biotech teams to present their innovations during a dedicated session “10 minutes to convince”.


The microbiome-to-host communication affecting pregnancy and fetal growth in early postnatal life


In his lecture presented durting the 2nd World Congress on Targeting Microbiota, which will be held at Pasteur Institute on October 16-17, 2014, Pr Sven Petterson will present some of  their recent findings on the maternal microbiome affecting placenta development and function and its possible implications to handle stress later in life. 

In addition, Pr Petterson will  also present some new data on microbiome mediated mechanims regulating ketonbody production through a novel transcription factor expressed in the liver.

For more information on Targeting Microbiota World Congress:

Uncultivated bacterial symbionts: a rich resource for drug development

JoernPielAccording Pr Joern Piel, from ETH Zurich: "Culturable bacteria provide many bioactive natural products that serve as an important basis for drug development. By extrapolation it has been proposed that the great diversity of as-yet unculturable prokaryotes represents a massive discovery resource for novel drug candidates.


You have until September 30 to submit your abstract for Poster Presentation for Targeting Microbiota World Congress

Sept30The Scientific Committee of Targeting Microbiota 2014 invites all academics, researchers and industrials to present their latest innovations and researches in Microbiota field.

Deadline for Poster Presentations Submission: September 30th

Deadline for "10 minutes to convince"  for Industrials & Start-ups: September 30th

 To access to all information about abstracts submission, please click here.

Microbiota, Oxidative Stress & Intestinal Redox Biology

microbioteThe scientific committee of Targeting Microbiota will discuss how oxidative stress can modulate microbiota diversity and quality, and the relation with chronic inflammatory diseases or general inflammation.


Mitochondria-Microbiota Crosstalk: The Intriguing Relationship


Interestingly, due to the prokaryotic origin of mitochondria, mitochondria and microbiota share commons features. Based on an evolutionary point of view, this common origin had profound effects in term of functional interaction with the host.


Microbiota in the Press & Media

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