Alerts
Microbiome Engineering: Reprograming microbes to rewire host-microbiome interactions
Dr. Matthew Chang from the National University of Singapore, Singapore will join the Targeting Microbiota 2023 congress and will talk about "Microbiome Engineering: Reprograming microbes to rewire host-microbiome interactions".
The wealth of knowledge on the human microbiota composition and its roles in health and disease has recently spurred the development of novel therapeutic strategies. Moreover, with an array of genetic tools that are readily available, programmable genetic circuits can be designed, genomes can be edited and rewritten, and cells can be reprogrammed to foster novel microbiota-based interventions.
In this talk, Dr. Chang's recent work on engineering gut-resident microbes as versatile platforms equipped with clinically relevant functionalities will be presented. A particular emphasis will be placed on his team's efforts to transform gut microbes into live biotherapeutics with prophylactic and therapeutic efficacy against pathogenic infections and chronic metabolic diseases.
This work provides a strong foundation for engineering microbes to modulate host-microbiome interactions and supports the use of live biotherapeutics as a viable strategy for clinical intervention.
About Dr. Chang
Matthew Chang is Director of the National Centre for Engineering Biology, Singapore Consortium for Synthetic Biology, Wilmar-NUS Corporate Laboratory, and NUS Synthetic Biology for Clinical and Technological Innovation, and Dean’s Chair in Medicine and Associate Professor of Biochemistry and Synthetic Biology at the Yong Loo Lin School of Medicine at the National University of Singapore. His research focuses on studying the engineering of biology to develop autonomous, programmable cells for biomedical and biomanufacturing applications. He co-founded the Global Biofoundry Alliance and the Asian Synthetic Biology Association and serves as Co-Chair of the World Economic Forum’s Global Future Council on Synthetic Biology.
Join Targeting Microbiota 2023 to learn more about Dr. Chang's talk.
You can share your related work by submitting your abstract.
Targeting Microbiota 2023 Congress
October 17-19, 2023 - Venice
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Environmental Drivers of Avian Enteric Neuroendocrine Plasticity in the Context of Foodborne Pathogen Carriage
Dr. Joshua Lyte, United States Department of Agriculture, Agricultural Research Service, USA, will join the Targeting Microbiota 2023 congress to talk about: "Environmental Drivers of Avian Enteric Neuroendocrine Plasticity in the Context of Foodborne Pathogen Carriage".
Environmental pressures represent an omnipresent threat across the diverse phases of poultry production in the 21st century. Research directed at mitigating the deleterious effects of environmental stress on the avian gastrointestinal tract necessitates the identification of mechanistic pathways that sit at the nexus of host and microbiota.
The research approach that Dr. Lyte and his team employed has its basis in common mechanistic pathways that are shared among diverse forms of environmental stressors. Those pathways principally involve the host’s neuroendocrine response to stress as well as the response of the gut microbiota whose composition and function are critical to gut homeostasis and avian well-being.
Microbial endocrinology, which is the study of the intersection of two seemingly disparate fields, neuroendocrine physiology and microbiology, and the bi-directional communication between both, that is at the core of our approach to devising new strategies to combat environmental stressors in food production animals. The remarkable integration of the bird’s neuroendocrine physiology and its microbiota is due to the evolutionary-based fact that each shares a range of neurochemicals, principally those related to the stress response, that permit bi-directional communication between the two that ultimately influences host gut function.
This talk will focus on the avian gut as the anatomical region where the host and microbiota interact and represents the area that can most easily be leveraged to deal with environmental stressors. As will be discussed, the design of new antibiotic alternative strategies that seek to manage the intersection of host neuroendocrine physiology and microbiota is one of the most promising avenues for dealing with the negative effects of environmental stress which may drive avian susceptibility to foodborne pathogen carriage.
Join Targeting Microbiota 2023 to learn more about Dr. Lyte's talk.
You can share your related work by submitting your abstract.
Targeting Microbiota 2023 Congress
October 17-19, 2023 - Venice
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Effect of Gut Microbiota Regulation on Non-Alcoholic Fatty Liver Disease
Dr. Yu Chen from The 7th Affiliated Hospital of Southern Medical University, China will join the Targeting Microbiota 2023 congress to talk about: "Effect of Gut Microbiota Regulation on Non-Alcoholic Fatty Liver Disease".
Non-alcoholic fatty liver disease (NAFLD) is currently the most prevalent cause of chronic liver disease. Alteration of the microbiota seem to be key in the development and progression of NAFLD. Gut microbiome regulation, such as Faecal Microbiota Transplantation (FMT) and supplementation in Akkermansia muciniphila , was paving the way as the therapeutic target for NAFLD.
Join Targeting Microbiota 2023 to learn more about Dr. Chen's talk.
You can share your related work by submitting your abstract.
Targeting Microbiota 2023 Congress
October 17-19, 2023 - Venice
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Gut Microbiota & Microbiota-Derived Metabolites Role in Endometriosis
Dr. Ramakrishna Kommagani from Baylor College of Medicine, USA will join the Targeting Microbiota 2023 congress to talk about: "Gut Microbiota & Microbiota-Derived Metabolites Role in Endometriosis".
Join Targeting Microbiota 2023 to learn more about Dr. Kommagani's talk.
You can share your related work by submitting your abstract.
Targeting Microbiota 2023 Congress
October 17-19, 2023 - Venice
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Microbiota and Interactions with Gut and the Enteric Nervous System
Prof. Karl-Herbert Schäfer from Kaiserlautern University of Applied Sciences, Germany will join the Targeting Microbiota 2023 congress to talk about: "Microbiota and Interactions with Gut and the Enteric Nervous System".
The gut contains billions of bacteria, that have long been neglected, and which have been seen, at best, as potential trouble makers in cases of diseases. During the last decades, the view of the enteric microbiome changed a lot. It is known now that it is influencing the quality of the gut barrier, producing legions of metabolites that influence both gut and enteric nervous system, changing i.e. gut motility or the inflammatory status of the gut wall.
Bacterial lipopolysaccharides might immediately impact i.e. the proliferation of neural stem cells within the ENS, or influence their differentiation. Bacteria can produce neurotransmitters such as GABA and serotonin, along with short chain fatty acids (SCFA) such as butyrate. Extracellular vesicles, produced by the bacteria, can carry this molecules along the mucosal barrier and might influence directly the activity of the ENS and thus the whole gut. Moreover, bacteria can produce Amyloid-like Protein Fibrils (ALFs) such as curli, which might initiate pathological processes in neurodegenerative diseases.
The impact of individual bacterial strains or LPS as a major molecule provided by gram negative bacteria upon gut and ENS has been investigated by Prof. Schäfer and his colleagues using primary cultures of the isolated myenteric plexus, analysing its growth or electrical responses after “bacterial” stimulation. Whole gut segments have been used in organ bath approaches to investigate alterations of gut motility when being perfused with bacteria or bacterial supernatants.
Join Targeting Microbiota 2023 to learn more about Prof. Schäfer's research and obtained data.
Targeting Microbiota 2023 Congress
October 17-19, 2023 - Venice
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Arresting microbiome development limits immune system maturation and resistance to infection in mice
Dr. Michael Silverman from the University of Pennsylvania, USA will join the Targeting Microbiota 2023 congress and will talk about "Arresting microbiome development limits immune system maturation and resistance to infection in mice".
Join Targeting Microbiota 2023 to learn more about Dr. Silverman's talk.
You can share your related work by submitting your abstract.
Targeting Microbiota 2023 Congress
October 17-19, 2023 - Venice
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Engineered Escherichia Coli for the in Situ Secretion of Therapeutic Nanobodies in the Gut
Dr. Cammie Lesser from Massachusetts General Hospital, Harvard Medical School, will join Targeting Microbiota 2023 on October 17-19 to present her latest research "Engineered Escherichia Coli for the in Situ Secretion of Therapeutic Nanobodies in the Gut".
Dr. Lesser will elaborate on the development of PROT3EcT, a platform of commensal and probiotic E. coli outfitted with a programmable secretion system. PROT3EcT can secrete functional single-domain antibodies (nanobodies), high-specificity therapeutics, into its surroundings. TNF-PROT3EcT, a variant that secretes TNF-alpha neutralizing nanobodies is as efficacious as systematically administered anti-TNF-alpha neutralizing monoclonal antibodies in inhibiting the development of colitis in a preclinical mouse model of Inflammatory Bowel Disease.
About Dr. Lesser
Dr. Lesser is a physician-scientist whose lab is interested in deciphering the ways that bacterial pathogens manipulate host cells to promote their own survival and dissemination. She has a long-standing interest in studying the pathogenesis of Shigella flexneri, focusing on its type III secretion system, a complex nanomachine that it uses to inject over 30 different proteins into human host cells. Projects in her lab focus on understanding how type III secreted proteins are defined as substrates, deciphering how they act to manipulate eukaryotic host cell processes, and most recently in engineering these secretion systems to develop engineered E. coli as a therapeutic protein delivery platform.
Join Targeting Microbiota 2023 to learn more about Dr. Lesser's talk.
You can share your related work by submitting your abstract.
Targeting Microbiota 2023 Congress
October 17-19, 2023 - Venice
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Multi-omics in Colon Cancer and Role of the Microbiome
Dr. Souhaila Al Khodor from Sidra Medicine, Qatar will join the Targeting Microbiota 2023 congress to talk about: "Multi-omics in Colon Cancer and Role of the Microbiome".
This study consisted of 348 treatment-naïve patients with colon cancer that were profiled using various omics including 16S rRNA gene sequencing and complemented with tumor whole-genome sequencing for further microbiome analysis. Dr. Al Khodor and her team characterized the immune-microbiota interactions in those patients and identified microbial signatures predictive of overall survival.
They identified a microbiome signature, driven by Ruminococcus bromii, that was associated with a favorable outcome. This study is a step forward toward implementing microbiota-targeting approaches, such as dietary intervention in the adjuvant or neoadjuvant setting.
Join Targeting Microbiota 2023 to learn more about Dr. Khodor's talk.
You can share your related work by submitting your abstract.
Targeting Microbiota 2023 Congress
October 17-19, 2023 - Venice
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Clinical Applications of Gut Microbiota: Gut Microbiome for Prediction of Colorectal Neoplasia
Dr. Francis K L Chan from The Chinese University of Hong Kong, China will join the Targeting Microbiota 2023 congress and will give a speech entitled "Clinical Applications of Gut Microbiota: Gut Microbiome for Prediction of Colorectal Neoplasia".
Join us in Targeting Microbiota 2023 and benefit from the experience of Dr. Chan. Don't forget that you can share your related work by submitting your abstract.
Targeting Microbiota 2023 Congress
October 17-19, 2023 - Venice
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Anthropology and Research on the Microbiome: Addressing Future Health
Prof. Roberta Raffaetà from Università Ca' Foscari Venezia, Italy will join the Targeting Microbiota 2023 congress and will give a presentation entitled "Anthropology and Research on the Microbiome: Addressing Future Health".
Prof. Raffaetà's talk will introduce the socio-anthropological debate and research on the microbiome and its implications for future health. It will particularly focus on the ERC HealthXCross project. This is a multi-sited, comparative ethnographic study of how technoscience is reconfiguring practices and ideas of health in ecological perspective.
Join us in Targeting Microbiota 2023 and benefit from the experience of Prof. Raffaetà. Don't forget that you can share your related work by submitting your abstract.
Targeting Microbiota 2023 Congress
October 17-19, 2023 - Venice
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Fecal Gut Microbiota and Metabolite Signatures as Biomarkers for Gastrointestinal Disorders
The organizing committee of the Targeting Microbiota 2023 congress, is honored to announce the participation of Prof. Lena Öhman from the University of Gothenburg, Sweden.
Prof. Öhman will give a major speech on "Fecal Gut Microbiota and Metabolite Signatures as Biomarkers for Gastrointestinal Disorders".
There is an urgent need to develop biomarkers for patients with gastrointestinal disorders. The talk will address the potential of fecal gut microbiota and metabolite signatures as biomarkers for inflammatory bowel disease and irritable bowel syndrome.
Join us in Targeting Microbiota 2023 and benefit from the experience of Prof. Öhman. Don't forget that you can share your related work by submitting your abstract.
Targeting Microbiota 2023 Congress
October 17-19, 2023 - Venice
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Gut Microbiota and Cancer Immunotherapy
Dr. Andrew Y. Koh from the University of Texas Southwestern Medical Center, USA will join the Targeting Microbiota 2023 congress and will give a speech entitled "Gut Microbiota and Cancer Immunotherapy".
Gut microbiota, specifically gut bacteria, are critical for effective immune checkpoint blockade therapy (ICT) for cancer. The mechanisms by which gut microbiota augment extraintestinal anticancer immune responses, however, are largely unknown. Dr. Koh and his team find that ICT induces the translocation of specific endogenous gut bacteria into secondary lymphoid organs and subcutaneous melanoma tumors.
Mechanistically, ICT induces lymph node remodeling and dendritic cell (DC) activation, which facilitates the translocation of a selective subset of gut bacteria to extraintestinal tissues to promote optimal antitumor T cell responses in both the tumor-draining lymph nodes (TDLNs) and the primary tumor. Antibiotic treatment results in decreased gut microbiota translocation into mesenteric lymph nodes (MLNs) and TDLNs, diminished DC and effector CD8+ T cell responses, and attenuated responses to ICT.
Those findings illuminate a key mechanism by which gut microbiota promote extraintestinal anticancer immunity
Join us in Targeting Microbiota 2023 and benefit from the experience of Dr. Koh. Don't forget that you can share your related work by submitting your abstract.
Targeting Microbiota 2023 Congress
October 17-19, 2023 - Venice
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The University of Padova is Locally Involved in Organizing Targeting Microbiota 2023
Prof. Maria Cecilia Giron from the University of Padova will be locally organizing The 10th World Congress on Targeting Microbiota 2023 in Venice on October 17-19.
The International Society of Microbiota look forward to meeting you in Venice for a conference that will target microbiota to unravel the future of medicine.
You can learn more about the Targeting Microbiota 2023 event organization in this press release.
Sessions of Targeting Microbiota 2023.
Targeting Microbiota 2023 Congress
October 17-19, 2023
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Targeting Microbiota 2023 will be held at Isola di San Servolo, Venice, Italy
The 10th World Congress on Targeting Microbiota 2023 will be held on October 17-19 at
Isola di San Servolo - Centro Soggiorno
Isola di San Servolo, 30124 Venice, Italy
Visit San Servolo Island's official website.
More about San Servolo Island
The island of San Servolo, immersed in the lagoon between San Giorgio and the Lido, houses in its rectangle of land a vast architectural complex and a beautiful park. Upon landing, you are immediately dominated by the giant spherical sculpture by Arnaldo Pomodoro, but in just a few steps everything disappears and you find yourself immersed in greenery, lost in silence and enchanted by the view of the lagoon and the care of the vegetation.
San Servolo is often selected to be used as an exhibition space and special events, such as the recurring More Festival, a great festival organized by France. The more experimental wing of the Academy of Fine Arts is also housed insidededicated to new technologies. A beautiful evolution for a place that has historically undergone a multitude of functions: from a spiritual refuge for Benedictine monks at the end of the 9th century, evidenced by the construction of a small church, up to a psychiatric hospital (if you can call it that in the 1700s), the main up to the law of Franco Basiglia to whose name the Foundation based in San Servolo is dedicated.
How to reach the island
Reaching San Servolo by Vaporetto
San Servolo can be reached in 8 to 10 minutes by vaporetto from St. Mark's square (Vaporetto stop: San Zaccaria – Pier B), Venice.
The vaporetto line is number 20. You can access the schedule here.
Reaching St. Mark's square to take the Vaporetto to San Servolo
You can reach St. Mark’s square from the airport :
- Either by boat with Alilaguna (orange line)
- Or by bus and vaporetto (you reach Piazzale Roma by bus and take a vaporetto for San Zaccaria)
More information about the transportation to San Servolo.
More information about the island's location.
Easy Access to Venice
As San Servolo Island is only a 10-minute vaporetto ride away, you can easliy and rapidly access Venice, one of the most famous cities of the world.
Every corner of Venice is a piece of History, an artwork, a place where to stand for a reflection about how great it was in the past.
Learn more about Venice tourism.
Book your Hotel
Many hotels are located near the island. Feel free to check and search for otels that are in the San Marco area.
ISM is now welcoming abstracts for Targeting Microbiota 2023
The 10th edition of the World Congress on Targeting Microbiota is being organized on October 2023.
Your latest research and innovations in the world of microbiota can now be considered for a short oral/ poster presentation during the conference. The abstract submission procedure is now activated.
The topics for this year include but are not limited to the following tracks.
Don't miss your chance to share your latest microbiota related research with international scientists!
Media contact:
International Society of Microbiota
[email protected]
Targeting Microbiota 2023 Congress
October 18-19, 2023
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Targeting Microbiota 2022 Captured Moments
Happy Holidays from the International Society of Microbiota. On behalf of the ISM organizing committee, we wish to share with you the captured moments of Targeting Microbiota 2022. All pictures of the 9th World Congress are now available.
Aside from reviewing the moments of this successful meeting that gathered more than 230 attendees worldwide, you can now demand access to the conference replay and 100+ abstracts.
Thanks to all attendees for their participation and scientific contributions to the vast microbiota world.
We wish to meet you all again next year and hear about your latest research and discoveries.
The International Society of Microbiota
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News Release, International Society of Microbiota, France – December 22, 2022
Prof. Maria Cecilia Giron Awarded for Her Scientific Contribution on Cancer Therapy and Microbiota
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Prof. Giron presented a strategic talk on "Cancer Therapy and Microbiota" on which she was discerned the Best Scientific Contribution Award during Trageting Microbiota 2022. Prof. Maria Cecilia Giron gave an overview of the influence of gut microbiota on ensuring the efficacy and lowering the toxicity of current cancer therapies. She is Associate Professor of Pharmacology at the University of Padova where together with her team is focused in targeting the interaction between innate immunity, enteric nervous system and microbiome in diverse intestinal inflammatory pathologies (e.g., Irritable Bowel Syndrome (IBS), Inflammatory Bowel Diseases (IBD) and Inflammation-Associated Colorectal Cancers) as well as in gut neuropathies including Multiple Sclerosis and Parkinson’s Disease in order to develop new pharmacological treatments and/or nutritional strategies. Dr. Giron currently serves as pharmacologist in the Ethics Committee for Clinical Studies of the Padova University Hospital, in the Ethics Committee for Oncological Clinical Trials of the Veneto Institute of Oncology and in the Veneto Region Medicines Evaluation Committee. She is a pioneer in research on the role of gut microbiota and intestinal function in normal and pathological conditions. She is author of more than 60 peer-reviewed publications, and co-founder of Eubiome, an innovative University spin-off and start-up, involved in FMT research and therapeutic applications of gut microbiota in human and animal recipients. The International Society of Microbiota allows you to access the full conference on demand. Prof. Maria Cecilia Giron's Presentation |
Targeting Microbiota 2022 Congress
October 19-21, 2022- Paris, France
www.microbiota-site.com
Short Oral Presentation Award 2022: Recombinant Lactic Acid Bacteria for IBD Therapy
Abida Zahirović, Jozef Stefan Institute, Slovenia, was awarded during Targeting Microbiota 2022 for her talk on "Recombinant Lactic Acid Bacteria for Therapy of Inflammatory Bowel Disease".
Dr. Zahirović shared with the International Society of Microbiota that her future research will be focussed on development of targeted bacterial delivery systems for anticancer agents.
She state: "In my PostDoc project, I aim to engineer lactic acid bacteria to display cancer cell-specific ligand on their surface and concomitantly secrete cytotoxic protein to achieve selective killing of cancer cells. In vivo tumour-targeting bacteria can increase intratumoral accumulation of a cytotoxic protein, thus restricting its activity to the tumour and sparing healthy tissue from toxic side-effects."
The Scientific Committee congratulates Dr. Zahirović again for her exceptional talk and look forward to hearing the outcome of her research in future meetings.
Targeting Microbiota 2022 Congress
October 19-21, 2022- Paris, France
www.microbiota-site.com
Short Oral Presentation Award 2022: Effects of the Unique Metabolism of Blautia Wexlerae on Obesity & Diabetes
Koji Hosomi, National Institutes of Biomedical Innovation, Japan was discerned the Best Short Oral Presentation Award 2022 for his talk entitled "Unique Metabolism of Blautia Wexlerae Has Beneficial Effects on the Control of Obesity and Type 2 Diabetes".
Dr. Hosomi sincerely congratulated the scientific committee for the award. He stated: "With this award as encouragement, I continues to vigorously research on the relationship between the microbiota and health, and hope to create academic knowledge that can contribute to improving people's health and controlling diseases."
The International Society of Microbiota looks forward to be updates with Dr. Hosomi's future research and congratulates him again.
Targeting Microbiota 2022 Congress
October 19-21, 2022- Paris, France
www.microbiota-site.com
Dr. Gilbert Skorski From Phylogene was awarded on his Poster during Targeting Microbiota 2022
"Metaproteomics As A Key Approach To Identify Impacts of High Fat (HIF) Diet on the Gut Microbiome" by Dr. Gilbert Skorski, Phylogene, France.
This strategic poster was awarded during Targeting Microbiota 2022. Dr. Skorski stated that the microbiomes understanding progresses depend on the available analytical tools of the meta-omics disciplines. Among those, metaproteomics is the omics which is ideally positioned at the effective functional level , not potential level, which has the power of metagenomics with the proteogenomics approach, and which detects the host and microbiome proteins simultaneously in an untargeted way.
Dr. Skorski shared with the International Society of Microbiota abouit his future work: "For the next steps, PHYLOGENE team will go on developing the metaproteomics and dedicated bioinformatics tools, including in transomics approaches, to reveal the microbiomes functions impacted in diseases or disease treatment of gut, skin, eyes, bones and cartilages and others…"
Thanks to Dr. Skorski for sharing this exceptional poster. The scientific committee look forward to learning all about his next project in Phylogene.
Targeting Microbiota 2022 Congress
October 19-21, 2022- Paris, France
www.microbiota-site.com
FMT 2022: Reorganization and Perspective
Prof. Peter C. Konturek, President of ISM from Teaching Hospital of the University of Jena, Germany will present a talk entitled "FMT 2022: Reorganization and Perspective".
Prof. Konturek will present new data on FMT and include important remarks on the reorganization of fecal microbiota therapy due to the SARS Cov2 Pandemic.
Targeting Microbiota 2022 Congress
October 19-21, 2022- Paris, France
www.microbiota-site.com
