Sex steroid deficiency-associated bone loss is microbiota dependent and prevented by probiotics

R.Pacifici Microbiota Paris2016

According Pr Roberto Pacifici, from Emory University School of Medicine, USA: "A eubiotic microbiota influences many physiological processes in the metazoan host, including development and intestinal homeostasis. Here (in our study), we have shown that the intestinal microbiota modulates inflammatory responses caused by sex steroid deficiency, leading to trabecular bone loss. [...] In germ-free (GF) mice, sex steroid deficiency failed to increase osteoclastogenic cytokine production, stimulate bone resorption, and cause trabecular bone loss, demonstrating that the gut microbiota is central in sex steroid deficiency–induced trabecular bone loss. [...] Together, these data highlight the role that the gut luminal microbiota and increased gut permeability play in triggering inflammatory pathways that are critical for inducing bone loss in sex steroid–deficient mice. Our data further suggest that probiotics that decrease gut permeability have potential as a therapeutic strategy for postmenopausal osteoporosis."

The scientific committee of the International Society of Microbiota is honoured to welcome Pr Pacifici during the 4th World Congress on Targeting Microbiota to be held on October 17-19, 2016 at Institut Pasteur, Paris.

For more information and registration:

Marvin Edeas, Chairman of ISM