Dr. Jasper will hightlight the age-related immune senescence and microbiota dysbiosis

JasperDr. Henri Jasper, Professor and CSO of the Buck Institute for Research on Aging in Novato, Canada, will give a presentation about Age-related immune senescence and microbiota dysbiosis: lessons from the fly, on the 4th World Congress on Targeting Microbiota.

Dr. Jasper’s lab studies the effects of aging on the intestinal microbiota, using Drosophila as a genetically accessible model system. Recent studies have uncovered a critical role for immune deregulation in the development of microbiota dysbiosis in aging animals. The work established that the intestinal epithelium of aging flies develops an inflammatory condition that is characterized by hyper activation of the Relish-NFkB signaling pathway, and results in expansion of the commensal microbiota, a secondary inflammatory response, and over-activation of intestinal stem cell proliferation. By preventing NFkB deregulation, the authors are able to delay these phenotypes and extend lifespan. Current work focuses on age-related changes in microbiota composition and compartmentalization, and new findings will be presented at the conference.

Find more information about the congress here: http://www.microbiota-site.com/
 

Dr. Jasper’s lab studies the effects of aging on the intestinal microbiota, using Drosophila as a genetically accessible model system. Recent studies have uncovered a critical role for immune deregulation in the development of microbiota dysbiosis in aging animals. The work established that the intestinal epithelium of aging flies develops an inflammatory condition that is characterized by hyper activation of the Relish-NFkB signaling pathway, and results in expansion of the commensal microbiota, a secondary inflammatory response, and over-activation of intestinal stem cell proliferation. By preventing NFkB deregulation, the authors are able to delay these phenotypes and extend lifespan. Current work focuses on age-related changes in microbiota composition and compartmentalization, and new findings will be presented at the conference.

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